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Anti-Peroxiredoxin II Monoclonal

Anti-Peroxiredoxin II Monoclonal

Price: $395.00

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NWA-PRX209A1

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Introduction

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b, k
Immunogen: Recombinant human protein purified from E.coli
Cross Reactivity
 Human, Mouse, Rat
Positive control:
 HeLa cell lysates
Application(s): ELISA Immunoprecipitation (1-2ul/400ul lysates) Immunocytochemistry (20ul/400ul)
Storage/Stability:
 Stable for 2 years at -20 °C
Packaging Size:
 100 μL
Format:
 Liquid
Concentration:
 1 mg/mL

References:
(1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40.
(2) Rhee Sue Goo, et al (2001) IUBMB life 52:35-41
(3) Min Hee Choi, et al (2005) Nature letters 435(19):347-353




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