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Anti-Methionine Sulfoxide Reductase A Polyclonal

Anti-Methionine Sulfoxide Reductase A Polyclonal

Price: $385.00

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NWA-MSRAP31

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Introduction

Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and -1-proteinase-inhibitor (1-3). Recent studies indicate that there is a connection between MsrA and Alzheimers disease in mammals (4).
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant human protein purified from E.coli
Cross Reactivity
 Mouse, Rat
Application(s): Western Blot: (1:2000)
Storage/Stability:
 Stable for 1 years at -20 °C
Packaging Size:
 100 μL
Format:
 Liquid
Concentration:
 0.5 mg/mL

References:
1) Sun, H. et al. (1999) Biochemistry. 38, 105-112.
2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311.
3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78,
7483-7486.
4) Gabbita, S. P. et al. (1999) J. Neurochem. 73, 1660-1666.




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