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Anti-Methionine Sulfoxide Reductase A Monoclonal

Anti-Methionine Sulfoxide Reductase A Monoclonal

Price: $375.00

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NWA-MSRA5B5

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Introduction

Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and -1-proteinase-inhibitor (1-3). Recent studies indicate that there is a connection between MsrA and Alzheimers disease in mammals (4).
Host: Murine
Clonality: Monoclonal
Isotype: IgG2b, ĸ
Immunogen: Recombinant human protein purified from E.coli
Cross Reactivity
 Human, Mouse, Rat
Application(s): Immunoprecipitation (1-2ul/400ul lysates)
Storage/Stability:
 Stable for 1 years at -20 °C
Packaging Size:
 100 μL
Format:
 Liquid
Concentration:
 1 mg/mL

References:
1) Sun, H. et al. (1999) Biochemistry. 38, 105-112.
2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311.
3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78,
7483-7486.
4) Gabbita, S. P. et al. (1999) J. Neurochem. 73, 1660-1666.




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