Human Cu/ZnSOD ELISA

Introduction

Superoxide Dismutases (SODs) are a unique family of metalloproteins that catalyze the dismutation of superoxide anion radicals (O₂-) to oxygen (O₂) and hydrogen peroxide (H₂O₂). SOD protects cells against oxygen-mediated free radical damage. Four types of SOD have been defined on the basis of their metal cofactors and distribution. The Cu/Zn form is the most common, with a primary distribution in the cytoplasm of of eukaryotic cells. The manganese form (MnSOD) is generally associated with the mitochondria of aerobic organisms. The iron (FeSOD) form is found predominantly in prokaryotes. The most recently discovered form, extra-cellular (ecSOD) is found in the extra-cellular fluids of mammalian species, often associated with vascular tissues.

The NWLSS™ Cu/ZnSOD ELISA is intended for the quantitative detection of human Cu/ZnSOD in human plasma, serum cell culture supernatants, erythrocyte (RBC) or other cell lysates and other biological fluids where SOD may be present.